Afterplay revisits the lives of two of characters, Andrey Prozorov and Sonya Serebriakova, who had a previous existence in two separate Chekhov plays, Three Sisters and Uncle Vanya respectively. Both characters are now middle-aged, but cannot escape the circumstances of their earlier lives; Andrey is still an only boy, confused, motherless and living in the remote rural town of Taganrog; Sonya is still deeply and hopelessly in love with the local doctor. Andrey now takes the train regularly from Taganrog to Moscow, allegedly to play as a violinist at the opera, Sonya is in Moscow to negotiate with the Ministry for Agriculture to try to save what's left of her dwindling estate. They meet by chance for one evening, twenty years after their previous fictional lives ended.